2021 03 v.32;No.103 298-303
一种基于质谱仪的数字滤波器参数设计方法研究
基金项目(Foundation):
国家重大科学仪器设备开发专项项目(No.2018YFF0109504)
邮箱(Email):
yxp@cjlu.edu.cn;jiangyou@nim.ac.cn;
DOI:
中文作者单位:
中国计量大学生命科学学院;中国计量科学研究院前沿计量科学中心国家市场监管技术创新中心;
摘要(Abstract):
目的:数字滤波器可以提高质谱仪信噪比。针对数字滤波器参数设置不当会降低质谱仪质量分辨率以及浪费系统资源的问题,提出一种数字滤波器参数设计的方法。方法:根据滤波前后质量分辨率变化规律、限定质量分辨率增量以及基线信号强度变化,完成了数字滤波器的窗函数、阶数及最佳截止频率的参数设计。结果:在实验室自主研制的四极杆-线形离子阱串联质谱仪中,使用本方法实现了hamming窗低通数字滤波器的设计,将仪器信噪比提升71%,同时分辨率降低量小于1%。结论:该方法在提高质谱仪信噪比和分辨率的同时,减少了系统资源浪费,为高灵敏质谱仪研发提供了参考方法。
关键词(KeyWords):
数字滤波器;;四极杆-线形离子阱串联质谱仪;;高质量分辨率;;信噪比
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参考文献
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[3] MARTINA B R,AIZIKOV K,MANDELSHTAM V A.The filter diagonalization method and its assessment for Fourier transform mass spectrometry[J].International Journal of Mass Spectrometry,2014,373:1-14.
[4] LIU Y,KESHAB K P.Linear-phase lattice FIR digital filter architectures using stochastic logic[J].Journal of Signal Processing Systems,2018,90(5):791-803.
[5] 付江铎，伍民顺，班诚，等.应用于高精度ADC频谱测试的改进加窗技术[J].电子测量与仪器学报，2020,34(5):9-15.FU J D,WU M S,BAN C,et al.Improved windowing technique applied to high-precision ADC spectrum measurement[J].Journal of Electronic Measurement and Instrument,2020,34(5):9-15.
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[7] WRIGHT S,MALCOLM A,WRIGHT C,et al.A microelectromechanical systems-enabled,miniature triple quadrupole mass spectrometer[J].Analytical Chemistry,2015,87(6):3115-3122.
[8] ZOU R,CAO W B,CHONG L,et al.Point-of-care tissue analysis using miniature mass spectrometer[J].Analytical Chemistry,2019,91(1):1157-1163.
[9] 刘磊，江游，刘梅英，等.四极杆质谱质量分辨自动调节技术研究[J].质谱学报，2020,41(2):118-124.LIU L,JIANG Y,LIU M Y,et al.Research on the mass resolution automatic adjustment technology of quadrupole mass spectrometry[J].Journal of Chinese Mass Spectrometry Society,2020,41(2):118-124.
[10] KUMAR S,SINGH K,SAXENA R.Analysis of dirichlet and generalized “Hamming” window functions in the fractional Fourier transform domains[J].Signal Processing,2011,91(3):600-606.
[11] WANG K F,WANG T H,YAO X Z,et al.Research on different realization methods of digital filter design based on MATLAB/Simulink[J].Electronic Measurement Technology,2017,40(1):17-25.
[12] 王坤非，王泰华，姚学召，等.基于MATLAB/SimulinkFIR数字滤波器设计的不同实现方法研究[J].电子测量技术，2017,40(1):17-25.WANG K F,WANG T H,YAO X Z,et al.Research on different realization methods of digital filter design based on MATLAB/Simulink[J].Electronic Measurement Technology,2017,40(1):17-25.
基本信息:
DOI：
中图分类号:TH702
引用信息:
[1]章燕妮,李畅,刘梅英等.一种基于质谱仪的数字滤波器参数设计方法研究[J].中国计量大学学报,2021,32(03):298-303.
基金信息:
国家重大科学仪器设备开发专项项目(No.2018YFF0109504)
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