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当今的生命科学研究可归纳为 3类 8个生命科学发展研究前沿问题 ,通过对这些问题的讨论 ,使研究者全面了解整个生命科学研究现状 ,明确今后发展研究方向和目的
Abstract:The advance of the research on life sciences can be qeneralized into 3 aspects and 8 major problems. Questions that would be solved in the research of life sciences have been discussed in this paper. A general view on the research of life sciences as a whole has been presented in article, as to understand the researching direction in the future.
[1] GAASTERLAND T,BEKIRANOV S.Making the most of microarray data[J].NatureGenet,2000,24:204-206.
[2] ERMOLAEVA O,RASTOGI M,PRUITT K D,et al.Data management and analysis for gene expressionarrays[J].NatureGenet,1998,20:19-23.
[3] BUL T C J,WHITE O,OL SEN G J.Complete genome sequence of the methanogenic archaeon,Methanococcus jannaschii[J].Science,1998,273:1058-1073.
[4] KL ENK H P,CL AYTON R A,TOMB JF,etal.The complete genome sequence of the hyperthermophilic,sulphate- reducing archaeonArchaeoglibus fulgidus[J].Nature,1997,390:364-370.
[5] KOONIM E V,MUSHEGIAN A R.Complete genome sequences of cellular life forms:glimpses of theoreti-cal evolutionary genomics[J].CurrOpinGenetDev,1996,6:757-762.
[6] PENNISI E.Genome data shake three of life[J].Science.1998,280:672-674.
[7] VIGILANT L.African populations and the evolution of human mitochoudrialDNA[J].Science,1991,253:1503-1507.
[8] NEI M.Molecular evolutionary genetics[M].ColumbiaUniversityPress,NewYork,1978.
[9] HORAI S.RecentAfrican origin of modern humans revealed by complete sequences of hominoid mitochon-drialDNAs[J].ProeNatlAcadSciUSA.1995,92:532-536.
[10] SANCHEZ R,SALI A.Comprarative protein structure modeling in genomics[J].ComputPhys,1999,151388-401.
[11] STERMBERT M JE.Protein structure prediction a practical approach.[M].Oxfiord:OxfordPress,1996.
[12] SIPPL M J.Knowledge based potentials for proteins[J].CurrOpinStrucBiol,1995,5:229-235.
[13] BRYANR S H.Evaluation ofThreading specificity and accuracy[J].Proteins,1996,26:172-185.
[14] TERWILL IGER T C.Structural genomic inNorthAmerica[J].NatureStruc,2000,7:935-939.
[15] HEINEMANU U.Structural genomics inEurope:slow start,strong finish?[J].NatureStrucBiol.,2000,7:940-942.
[16] YOKOYAMA S,HIROTAL H,KIGAWA T,et al.Structural genomics projects inJapan[J].NatureStrueBiol,2000,7:943-945.
[17] BRENNER S.Target selection for structural genomics[J].NatureStrucBiol,2000,7:967-969.
[18] CLYDE A,HUTCHINSON III,SCOTT N,etal.Global transposon mutagenesis and a minimal mycoplas-ma genome[J].Science,1999,286:2165-2169.
[19] EUGENE V K.How many genes can make a cell:the minimal- gene- set concept[J].AnnualReviewsGe-nomics andHumanGenetics,2000,1:99-116.
[20] YOUNT B,KRISTOPHER M C,RALPH S.Basic strategy for systematic assembly of largeRNA andDNA genomes:transmissible gastroenteritis virus model[J].Journal ofVirology,2000,74(22):10600-10611.
[21] SCHNEIDER G,WREDE P.Artificial neural networks for computer- based molecular design[J].ProgBio-physMolecularBiol,1998,70:175-222.
[22] KHAN J,WEIJS,RINGNER M,et al.Classification and diagnostic prediction cancers using gene expres-sion profiling and artificial neural networks[J].NatMed,2001,7:673-679.
[23] ASTHAGIRI A R,LAUFFENBURGER D A.Bioengineering models of cell signaling biomed[J].EngAn-nuRev,2000,2:31-53.
[24] BUTLER D.Computing2010:from black holes to biology[J].Nature,1999,402:67-70.
[25] TOMITA M.Whole- cell simulation:a grand challenge of the21stcentury[J].TrendsBiotechol,2001,19:205-210.
[26] SLEPCHENKO B M.SCHAFF JC,CHOI Y S.Numerical approach to fast reactions in reaction- diffusionsystems:application to buffered calcium waves in bistable models[J].JComputPhy,2000,162:186-128.
[27] NORMIL ED D.Building working cells'in silico'[J].Science,1999,284;80-81.
[28] HALIM N S.News biological:the virtual cell:modeling cellular processes[J].Scientist,1999,13:181-183.
[29] MCCARTHY JJ,HILFIKER R.The use of single- nuleotide polymorphism maps in pharmacogenomics[J].NatBiotechnol.2000,8:505-508.
[30] ROSES A D.Pharmacogenetics and the practice of medicine[J].Nature,2000,405:857-865.
[31] LOCKHART D J,WINZELER E A.Genomics,gene expression andDNA arrays[J].Nature,2000,405:827-836.
[32] RISCH N J.Searching for genetic determinants in the new millennium[J].Nature,2000,405:847-856.
[33] DUGGAN D J,BITTNER M,CHEN Y,et al.Expression profiling using cDNA microarrays[J].NatGenet,1999,21:10-14.
[34] 赵国屏.生物信息学[M].北京:科学出版社,2002
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DOI:
中图分类号:Q1-0
引用信息:
[1]王兰州.生命科学研究前沿的若干问题[J].中国计量学院学报,2002(03).
基金信息:
中央与地方共建高等学校专项资金项目